Advancing Oral IL-23 Inhibition for Inflammatory Disease

Avere Therapeutics is developing AVR-001, an oral, once-weekly interleukin-23 receptor antagonist (IL-23RA) designed to deliver both convenience and competitive efficacy.

IL-23 is one of the most validated targets in immunology, with clinical proof-of-concept data firmly established across psoriasis, ulcerative colitis, Crohn’s disease, and psoriatic arthritis. Multiple IL-23 inhibitors have been approved, demonstrating the potential safety of this treatment strategy.

AVR-001 builds on that foundation – it is engineered for higher, more consistent drug exposure and a longer half-life that potentially enables delivery in a convenient, once-weekly pill. AVR-001 represents a potentially meaningful improvement in treatment for people living with chronic inflammatory disease.

Avere marks a new frontier – IL-23 inhibition in a once-weekly pill